MicroRNAs in hepatic pathophysiology
نویسندگان
چکیده
منابع مشابه
[MicroRNAs and intestinal pathophysiology].
MicroRNAs (miRNAs) represent an abundant class of endogenously expressed small RNAs, which is believed to control the expression of proteins through specific interaction with their mRNAs. MiRNAs are non-coding RNAs of 18 to 24 nucleotides that negatively regulate target mRNAs by binding to their 3'-untranslated regions (UTR). Most eukaryotic cells utilize miRNA to regulate vital functions such ...
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MicroRNAs (miRNAs) are a family of small, noncoding RNAs that repress gene expression at the post-transcriptional level. Over 700 miRNAs have been identified in the human genome, of which 20% to 30% regulate human protein-coding genes. Functional in vitro studies have shown that miRNAs are critical for endothelial cell gene expression and function. miRNAs were found in atherosclerosis, cardiac ...
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Background Colorectal cancer (CRC) is one of the leading causes of cancer-related mortality worldwide. Majority of the cases (~92%) are sporadic (nonhereditary), while the hereditary types constitute a lower percentage. The pathogenesis of sporadic CRC is heterogeneous and multi-factorial. In addition to environmental exposure, diet and lifestyle; accumulation of random somatic mutations also s...
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RNAs not encoding proteins have gained prominence over the last couple of decades as fundamental regulators of cellular function. Not surprisingly, their dysregulation is increasingly being linked to pathology. Here, we review recent reports investigating the pathophysiological relevance of this species of RNA for the cardiovascular system, concentrating mainly on recent findings on long noncod...
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MicroRNA (miRNA) are an important class of non-coding RNA which function as post-transcriptional regulators of gene expression in cells, repressing and fine-tuning protein output. Prolonged seizures (status epilepticus, SE) can cause damage to brain regions such as the hippocampus and result in cognitive deficits and the pathogenesis of epilepsy. Emerging work in animal models has found that SE...
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ژورنال
عنوان ژورنال: Hepatology Research
سال: 2016
ISSN: 1386-6346
DOI: 10.1111/hepr.12730